Tennessee vs. Iowa State odds, March Madness predictions: 2026 NCAA Tournament Sweet 16 picks by proven model

Why it matters: Expert predictions are shaping expectations for the high-stakes 2026 March Madness Sweet 16 and Elite Eight.
- SportsLine's model has simulated the Iowa State Cyclones vs. Tennessee Volunteers game, providing specific college basketball picks for this men's Sweet 16 matchup.
- CBS Sports is also offering predictions, focusing on the Michigan State vs. UConn odds for the men's Sweet 16 and later, expert picks and odds for the Elite Eight games.
- ESPN provides broader coverage of the Women's March Madness 2026, offering previews of Friday's Sweet 16 games.
- CBS Sports additionally details the comprehensive 2026 NCAA Tournament schedule, including bracket information, game dates, locations, tip times, and TV channels, offering a full logistical picture of March Madness.
As the 2026 NCAA Tournament Sweet 16 heats up, SportsLine's model has made its predictions for the Iowa State vs. Tennessee men's basketball matchup, while other sources are also weighing in on key games and the broader tournament landscape. The focus is on expert picks and odds for both men's and women's brackets, with an eye towards the Elite Eight.

