What this AI epitope library means for vaccines, immunotherapy and biosensors
Why it matters: This AI-driven epitope library accelerates the development of new vaccines, immunotherapies, and point-of-care diagnostic tools.
- CIC biomaGUNE developed epiGPTope, an AI-based system that generates and classifies epitopes, in collaboration with Multiverse Computing.
- Epitopes are small protein fragments recognized by antibodies or immune cell receptors, crucial for triggering an immune response against viruses or bacteria.
- The Biomolecular Nanotechnology laboratory is building a library of hundreds of thousands of synthetic epitopes, published in ACS Synthetic Biology, enabling faster and more cost-effective discovery.
- Aitor Manteca explains that the system identifies synthetic epitopes similar to natural ones, which can be recognized by antibodies, and determines their bacterial or viral origin.
- Microfluidic systems are used to analyze these protein fragments, allowing millions of different epitope-antibody combinations to be tested rapidly and cost-effectively in tiny droplets.
CIC biomaGUNE, in collaboration with Multiverse Computing, has developed epiGPTope, an AI-powered system that rapidly generates and classifies millions of synthetic epitopes, the protein fragments recognized by the immune system. This innovative tool allows researchers to quickly identify and categorize epitopes by their viral or bacterial origin, significantly accelerating the development of vaccines, immunotherapies, and diagnostic biosensors.
