Zach Cregger's *Resident Evil* reboot is on track for a franchise-best $40-60M opening weekend, with $8.8M already from previews. Sony's $75M bet on Cregger's horror cred and game-like approach signals a potential profitable re-establishment for the dormant series. Watch for its global opening, eyeing $80M, and how it impacts the video-game-to-film pipeline.