NFL Week 4 injuries: Jefferson, Donald out; 3 QBs sidelined — SkimNews

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- Justin Jefferson (Vikings) was ruled out for Week 4 due to injury, joining Aaron Donald (Rams, back) and Christian Gonzalez (Patriots, shoulder) on a swelling injury report filled with stars sidelined.
- Jayden Daniels (elbow) ruled out for the Commanders' London game against the Colts, sending Marcus Mariota into a second consecutive start; Terry McLaurin was added to the report Friday with a hamstring injury after being limited in practice.
- Caleb Williams will miss another Bears game recovering from a hamstring injury, and head coach Ben Johnson has yet to name a starter between Tyson Bagent and Case Keenum.
- Baker Mayfield officially ruled out for Tampa Bay with a right thumb injury, clearing the way for undrafted rookie Jalon Daniels to make his first NFL start; Bucky Irving returns at full strength in the backfield after being limited earlier in the week with a glute injury.
- Puka Nacua (hip) cleared with no designation and returns for the Rams against an Eagles team missing DeVonta Smith (hamstring) and Zack Baun (concussion).
- Trey Hendrickson is out after having a procedure on his broken finger, though the Ravens appear to be resting — not ruling out — Zay Flowers (hamstring) and Ronnie Stanley (toe), both listed as questionable.
- The New York Giants enter their matchup against Arizona as the only fully healthy team on the Week 4 slate with zero injury designations.
Why it matters: Three starting quarterbacks (Daniels, Williams, Mayfield) are sidelined in the same week for the first time this season, forcing the Buccaneers to start undrafted rookie Jalon Daniels and leaving the Bears' starter an open question between Bagent and the 37-year-old Keenum. With Jefferson, Donald, Gonzalez, and Hendrickson also out, Week 4 outcomes will be decided by backups and depth pieces rather than star talent.
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