How to bet on 2026 NFL Week 1: Betting guide, odds, trends, schedule, game previews, promo codes, offers — SkimNews
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- Seahawks-Patriots open the 2026 NFL season Wednesday at 8:15 p.m. ET as a Super Bowl rematch, with Seattle favored by 3.5 points and the over/under at 44.5; New England will play without running back TreVeyon Henderson due to an ankle injury.
- Rams-49ers meet Thursday Sept. 10 at Melbourne Cricket Ground in Australia, with Los Angeles favored by 3.5 and the total at 48.5 — the Rams added defensive star Myles Garrett in the offseason, while San Francisco dealt with preseason injuries and chose to arrive a week early to adjust to the 17-hour time difference.
- Ravens-Colts on Sunday marks Baltimore's first game without 18-year head coach John Harbaugh, as new coach Jesse Minter (the Chargers' former defensive coordinator) debuts with a healthy Lamar Jackson, Derrick Henry, and newly-paid Zay Flowers; Indianapolis gets back quarterback Daniel Jones from a torn Achilles.
- Browns-Jaguars features Cleveland under new head coach Todd Monken after a 5-12 season and the trade of reigning Defensive Player of the Year Myles Garrett to the Rams, while Jacksonville brings back a 13-4 squad led by Trevor Lawrence's 4,007-yard passing season.
- Buccaneers-Bengals puts Baker Mayfield in a contract year without Mike Evans (who signed with the 49ers), against a Cincinnati team that overhauled its 30th-ranked scoring defense by trading for Dexter Lawrence and signing Jonathan Allen and Boye Mafe.
- Broncos-Chiefs closes Week 1 on Monday Night Football with Kansas City favored by 2.5 and the total at 43.5, while the Sunday night finale has Dallas as a 2.5-point road favorite over the Giants.
- Online sports betting is legal in more than 30 states plus Washington D.C. and Puerto Rico, with DraftKings, FanDuel, bet365, BetMGM, Hard Rock Bet, Fanatics Sportsbook and Caesars all running Week 1 promos offering up to $1,500 in bonus bets.
Why it matters: With 16 games spanning four days and online betting legal in 30-plus states, sportsbooks are competing aggressively for Week 1 action with bonuses up to $1,500. Bettors also get their first look at major roster and coaching moves — Myles Garrett's switch from Cleveland to the Rams, and Baltimore's debut without John Harbaugh — that will frame the season's early narrative.
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