Miami vs. Clemson prediction, odds, time: Week 5 college football picks by proven model — SkimNews
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- Miami (Fla.) is a 15.5-point road favorite over Clemson at Memorial Stadium in Clemson, S.C., with kickoff at 7:30 p.m. ET and the over/under set at 48.5 in the latest odds.
- #4 Miami enters 4-0 overall and 3-0 in ACC play after a 52-3 rout of Central Michigan, while Clemson is 3-1 overall and 2-0 in the ACC after a 24-10 win over California.
- SportsLine's model projects 50 total points after simulating the game 10,000 times, making the Over 48.5 its value pick; the Over has hit in five of the last seven head-to-head meetings, including each of the last two.
- Miami junior quarterback Darian Mensah has completed 88.7% of his passes for 1,211 yards with 14 touchdowns and zero interceptions through four games, adding 52 rushing yards and a score on the ground.
- Clemson sophomore running back Gideon Davison has carried 59 times for 346 yards (5.9 average) and three touchdowns this season and is the focal point of the Tigers' run game.
- Clemson is 0-1 against ranked opponents in 2026, while the Hurricanes went 13-3 and reached the national championship game in 2025; Clemson finished 7-6 overall and 4-4 in the ACC last year.
- SportsLine's model enters Week 5 on a 34-25 run on top-rated college football picks, a stretch the outlet says has returned nearly $600 for $100 players.
Why it matters: With Miami 4-0 and a double-digit road favorite, bettors weighing the spread must weigh a 15.5-point line against Clemson's 0-1 mark vs. ranked foes and a Miami offense that has yet to commit a turnover through the air — a contrast that explains why the model's primary value call is the Over rather than a side. The matchup also frames early ACC title-race implications, as both teams enter 2-0 in conference play.
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