What to know for NFL Week 3: 15 games on deck, 15 previews from our reporters and experts — SkimNews

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- Justin Herbert and the 0-2 Chargers visit the 2-0 Bills, where Herbert has a 24% chance of throwing two or more interceptions per ESPN's model; Buffalo is the third team in NFL history to start 2-0 while allowing 30+ points in both games, and no team has ever started 3-0 under those conditions.
- Drake Maye and the Patriots face the Jaguars in Jacksonville, where the Jaguars are 8-1 ATS at home under coach Liam Coen; Maye has taken six sacks and thrown four interceptions this season against a defense that has held opponents to 5-for-19 on third down.
- Marcus Mariota will start at quarterback for the 0-2 Commanders against the Seahawks in place of injured Jayden Daniels (elbow); the Commanders have allowed an NFL-worst seven touchdown passes in two games and a 14-game streak without winning the turnover battle, tied for the franchise's longest drought since 1933.
- The Falcons beat the Packers 35-14 in Thursday's opener to launch the Week 3 slate.
- ESPN's analyst team — Seth Walder, Ben Solak, Eric Moody, and Pam Maldonaldo — provides bold predictions, watchability ratings, fantasy intel, and betting insights for each matchup, alongside Football Power Index (FPI) game projections.
- Monday Night Football closes the slate with the Eagles visiting the Bears on ESPN.
Why it matters: Week 3 is a critical early-season inflection point: the Chargers' viability hinges on whether Herbert can reverse an 0-2 start against a Bills team that has never started 3-0 while allowing 30+ points every game, while the Commanders face a test of their league-worst pass defense (seven TD passes allowed in two games) against Seattle's top-ranked scoring defense.
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