Week 2 NFL odds, picks, predictions: Computer model backs Seahawks and Buccaneers — SkimNews
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- SportsLine's computer model released its Week 2 NFL picks for the 2026 season, simulating every game 10,000 times and entering the week on a 53-39 run on top-rated picks dating back to 2024, with over $7,000 returned for $100 players since inception.
- The Seahawks are projected to cover a 4-point spread at Arizona in Sunday's 4:25 p.m. ET kickoff in nearly 60% of simulations; Seattle is 6-1 ATS when holding a rest advantage since 2025 and has won nine straight against the Cardinals (8-1 ATS).
- The Buccaneers are backed to cover 8.5 points versus the Browns in over 50% of simulations, with the Over hitting more than 60% of the time; Cleveland allowed 34 points and five sacks of Deshaun Watson in Week 1 and is 4-14 ATS on the road since 2024 — the NFL's worst road mark.
- The 49ers are 13.5-point favorites over Miami — the largest spread of the young NFL season — while the Rams are 7.5-point favorites over the Giants on Monday, with both teams returning home after playing in Australia in Week 1.
- Seahawks QB Sam Darnold is listed as out for the Arizona game, yet the model still projects Seattle to cover, framing the pick as a matchup fade rather than a Darnold endorsement.
- Six Week 2 games carry spreads of at least a touchdown, with the model also revealing an underdog it projects wins outright by a touchdown.
Why it matters: The model's two strongest Week 2 plays lean on situational data — Seattle's 9-game win streak against Arizona and Cleveland's 4-14 ATS road record, the NFL's worst — rather than quarterback-driven projections, since Darnold is out and the Bucs are coming off a Week 1 loss. Oddsmakers are pricing in Week 1 results aggressively, with six games carrying spreads of at least a touchdown and the 49ers-Miami line (13.5) the largest in the young season.
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