Rochester gene transfer boosts mouse lifespan
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- University of Rochester researchers inserted a naked‑mole‑rat longevity gene into mice, raising their production of high‑molecular‑weight hyaluronic acid.
- Modified mice displayed stronger tumor resistance, healthier gut microbiota, and lower age‑related inflammation.
- Median lifespan of the engineered mice rose by about 4.4% versus normal mice.
- Vera Gorbunova and colleague Andrei Seluanov reported the results in Nature (2023), calling it proof‑of‑principle that longevity traits can be transferred across species.
Why it matters: Biotech firms and aging patients gain a new therapeutic target—high‑molecular‑weight hyaluronic acid—potentially cutting cancer and inflammation treatment costs while extending healthspan, as the study proves the gene’s cross‑species efficacy.
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