NFL DFS, Chiefs vs. Colts: Best daily Fantasy picks, lineup advice for Sunday Night Football — SkimNews
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- Patrick Mahomes accounted for three total touchdowns in his Week 1 return from ACL surgery and completed 12 of his last 14 passes, and the Colts just allowed Lamar Jackson 324 passing yards — the fourth most of his career.
- Keenan Allen led Indianapolis with six catches in Week 1 and was the only Colts receiver targeted inside the 10-yard line; he has posted 55+ receiving yards or a touchdown in eight of his last nine games against Kansas City.
- Kansas City's run defense ranked in the top 10 in 2025 and allowed the second-fewest rushing yards of any team in Week 1, pointing DFS players toward the passing game for both sides.
- SportsLine's Mike McClure built his model around matchups, statistical trends, and injuries, and has more than $2 million in career DFS winnings including two tied finishes in the DraftKings Millionaire Maker.
- Sleeper candidates mentioned include Chiefs kicker Harrison Butker (five field goals in last year's Colts matchup) and Colts tight end Andrew Ogletree, who scored when these teams met last November.
- Kenneth Walker earned mention after his impressive Kansas City debut, while Jonathan Taylor and rookie tight end Tyler Warren anchor the Indianapolis side of the player pool.
Why it matters: For DFS players on FanDuel and DraftKings, McClure is stacking his lineups around two specific matchup edges: Mahomes exploiting a Colts secondary that just gave up 324 yards to Jackson, and Allen benefitting from a Chiefs defense that forces opponents to throw. The model's track record — $2M+ in winnings and two Millionaire Maker titles — gives the picks weight that casual lineup construction lacks.
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