AI generates millions of synthetic epitopes for
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- CIC biomaGUNE developed epiGPTope, an AI-based system that generates and classifies epitopes, in collaboration with Multiverse Computing.
- Epitopes are small protein fragments recognized by antibodies or immune cell receptors, crucial for triggering an immune response against viruses or bacteria.
- The Biomolecular Nanotechnology laboratory is building a library of hundreds of thousands of synthetic epitopes, published in ACS Synthetic Biology, enabling faster and more cost-effective discovery.
- Aitor Manteca explains that the system identifies synthetic epitopes similar to natural ones, which can be recognized by antibodies, and determines their bacterial or viral origin.
- Microfluidic systems are used to analyze these protein fragments, allowing millions of different epitope-antibody combinations to be tested rapidly and cost-effectively in tiny droplets.
Why it matters: This AI-driven epitope library accelerates the development of new vaccines, immunotherapies, and point-of-care diagnostic tools.
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