College football betting: Three-leg Week 4 parlay includes Oregon-USC, Iowa-Michigan — SkimNews

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- SportsLine Projection Model released a three-leg Week 4 college football parlay: USC money line vs. Oregon, Iowa money line vs. Michigan, and South Carolina +12.5 vs. Alabama, with all three legs available via DraftKings Sportsbook.
- USC (4-0) hosts Oregon (2-1) in a Big Ten clash with College Football Playoff implications; the model projects USC wins outright in 58% of simulations at plus-money odds, despite Oregon having won each of the last five meetings dating to 2016.
- Michigan (3-0) hosts undefeated Iowa in a game where the loser faces an uphill CFP path; the model projects Iowa wins outright in 48% of simulations at plus-money odds in what it expects to be a defensive, run-game-driven battle.
- Alabama (3-0) is a 13.5-point home favorite over South Carolina (2-1) despite giving up 36 points to Florida State and trailing Kentucky at halftime earlier this season; the model projects the Gamecocks cover +12.5 in 66% of simulations.
- SportsLine Projection Model is 22-19 on top-rated college football picks this season and has been upgraded for 2026 to better factor in transfer portal movement, simulating every FBS game 10,000 times.
- DraftKings is offering $150 in bonus bets when bettors spend $5 or more on Week 4 college football, the sportsbook promotion attached to the parlay pick card.
Why it matters: For college football bettors, the SportsLine model's parlay is a coordinated fade of the market's three biggest Week 4 favorites — all three legs sit at plus money or plus the spread — meaning a single wager wins only if every underdog performs to or above simulation expectations. Each game carries direct College Football Playoff seeding consequences: a USC or Michigan loss reshapes the Big Ten CFP picture, while Alabama dropping a home game to South Carolina would mark the Crimson Tide's first 2026 loss.
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