College football score predictions for Week 1, 2026: Computer backs Penn State (-23.5) against Marshall — SkimNews

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- Penn State is projected to beat Marshall 37-12 by SportsLine's model, which simulated every FBS game 10,000 times, making the Nittany Lions (-23.5) the value against the spread with the Under (52.5) on the total.
- Matt Campbell makes his Penn State debut after leaving Iowa State, bringing a couple dozen Cyclones via the transfer portal including quarterback Rocco Becht; more than half the roster is portal-built.
- Marshall went 5-7 last season and enters with unresolved questions on the offensive line and defense, which the model cites as the basis for the lopsided projection.
- SportsLine's model is on a 32-19 run on top-rated college football money-line picks since the 2024 season and was upgraded for 2026 to better factor in the transfer portal.
- Many outgoing Penn State players followed former head coach James Franklin to Virginia Tech or defensive coordinator Jim Knowles to Tennessee, deepening the roster overhaul Campbell inherited.
- Other Week 1 notable lines include LSU as a 10-point favorite over Clemson and Ole Miss -6.5 against Louisville, the weekend's only ranked-on-ranked matchup.
Why it matters: The model's 32-19 money-line record gives weight to a heavy Penn State lean, but the story is equally about roster construction: Campbell transplanted an Iowa State nucleus to Happy Valley while stars followed Franklin and Knowles out the door. Marshall's 5-7 finish and unsettled lines explain the steep 23.5-point spread.
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