College football picks: Predictions against the spread, odds, betting lines for top 25 games in Week 4 — SkimNews
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- Texas A&M visits No. 10 LSU on Saturday at 7:30 p.m. ET on ESPN, with the source noting no team has ever made the College Football Playoff after starting 0-2 in conference play; the source picks LSU -7.5 after Texas A&M's "embarrassing" home loss to Kentucky.
- No. 1 Texas travels to No. 14 Tennessee at noon ET on ABC, with the source highlighting Arch Manning's inconsistency — dominant in a comeback win over Ohio State but shaky against UTSA — and calling Tennessee true freshman QB Faizon Brandon's first start a "star-making opportunity."
- No. 4 Ole Miss heads to No. 21 Florida at 3:30 p.m. ET on ABC "fresh off a win over former coach Lane Kiffin" per the source, facing first-year Florida coach Pete Golding in The Swamp; the source picks the over at 58.5, citing defensive vulnerabilities on both sides.
- No. 2 Georgia plays Oklahoma at 3:30 p.m. ET on ESPN with QB Gunner Stockton ranked third among Power Four quarterbacks in efficiency behind Ole Miss's Trinidad Chambliss and Miami's Darian Mensah — a player "no one's talking about," per the source — and the pick is under 43.5.
- No. 17 Iowa travels to No. 18 Michigan in a game the source picks Iowa straight up at +178 odds, citing running back Kamari Moulton and wide receiver Tony Diaz as one of the Hawkeyes' best RB-WR combinations in 20 years.
- No. 20 Oregon visits No. 12 USC at 7:30 p.m. ET on NBC already carrying an early loss to Oklahoma State, with coach Dan Lanning facing criticism over his coordinator hires; the source picks the over at 61.5, noting USC and Oregon combined for 69 points in their 2025 meeting.
Why it matters: Week 4 stacks six top-25 games into one day — the most in three years — and the source frames it as the moment College Football Playoff pretenders get separated from contenders before September even ends. The LSU/Texas A&M loser starts 0-2 in SEC play, a deficit no team has ever overcome to reach the playoff, per the source.
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