College football picks: Predictions against the spread, odds, betting lines for top 25 games in Week 4 — SkimNews

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- Week 4 college football slate includes six top-25 matchups — the most in a single week in three years — beginning at noon ET with No. 1 Texas visiting No. 14 Tennessee.
- No. 23 Texas A&M's trip to No. 10 LSU carries elimination stakes; the article notes no team has ever made the College Football Playoff after starting 0-2 in conference play, and the pick is LSU -7.5.
- No. 18 Michigan is picked to be upset by Iowa at +178 straight-up after "living on borrowed time" all season, including a stunning Hail Mary win over Western Michigan.
- No. 2 Georgia quarterback Gunner Stockton is called one of the most efficient Power Four signal-callers alongside Ole Miss's Trinidad Chambliss and Miami's Darian Mensah; the Georgia-Oklahoma pick goes under 43.5.
- No. 20 Oregon faces a must-win at No. 12 USC (over 61.5) after a bad loss to Oklahoma State, with coach Dan Lanning already under fire for his coordinator hires.
- No. 4 Ole Miss visits No. 21 Florida (over 58.5) with questions about an emotional hangover after beating former coach Lane Kiffin.
Why it matters: Six ranked matchups on one Saturday — the most in three years — arrive just as College Football Playoff contenders face do-or-die conference tests; per the article's data, a 0-2 conference start has historically eliminated every team from the 12-team playoff, meaning Saturday's losers aren't just behind — they're functionally out. Bettors and fans get rare scheduling density, but Texas A&M and LSU essentially play a September elimination game.
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