NFL odds: Week 2 parlays featuring favorites, underdogs include Giants vs. Rams, Jaguars vs. Broncos — SkimNews
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- Mike Tierney, SportsLine expert who is 320-271-16 on the NFL over four seasons (130-101 ATS the past two), published two Week 2 parlays — one favorites, one underdogs — for the slate beginning Thursday, Sept. 17 with Lions at Bills.
- Cowboys, Chargers and Rams anchor Tierney's favorites money-line parlay: Dallas vs. Washington (he notes the Eagles 'wrote the game plan' for beating the Commanders), L.A. Chargers vs. Raiders (a 'placeholder QB' unlikely to start 2-0), and L.A. Rams vs. Giants (McVay's team has bounced back from Week 1 losses nearly three-fourths of the time).
- Jets, Vikings and Jaguars make up the underdogs parlay: New York vs. a Packers squad that has dropped six straight dating to last season, Minnesota at Chicago in a 'old-school division rivalry,' and Jacksonville at Denver after the Broncos were outgained 392-176 by Kansas City.
- Vikings defensive coordinator Brian Flores, per Tierney, could borrow blitz-heavy looks that limited Caleb Williams to 19 points in the latest meeting; Chicago scored 59 on Carolina in Week 1.
- Rams return the league's most productive 2025 offense intact, with Aaron Donald potentially 'launching his resurrection,' according to Tierney, who says to 'draw a line through its inexplicable debut' Down Under.
- Vikings QB Kyler Murray was injured before the end of his Minnesota debut, though Tierney sees 'little drop-off to Carson Wentz.'
Why it matters: Bettors shopping for Week 2 action get a two-pronged model from a handicapper hitting 56.3% against the spread: the favorites parlay leans on bounce-back spots (Cowboys, Chargers) plus a rested Rams offense, while the underdogs parlay targets vulnerable division opponents and a Broncos team in a short week after a 392-176 beating.
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