Psilocybin Dose Triggers Brain Structure Changes
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- Robin Carhart‑Harris led a study of 28 healthy volunteers that tracked brain changes after a 25 mg psilocybin dose.
- Imperial College London reported diffusion tensor imaging revealed reduced water diffusion in front‑to‑midbrain tracts a month after the psychedelic experience.
- UCSF researchers recorded a surge in brain entropy within an hour of psilocybin ingestion using EEG, indicating more varied neural activity.
- psilocybin induced anatomical brain changes that persisted for at least a month, a finding opposite to the degeneration seen in aging and dementia.
Why it matters: Mental‑health clinicians gain a measurable brain‑structure marker from 28 study participants, enabling more precise evaluation of psychedelic therapies and accelerating drug‑development pipelines, which speeds regulatory approval for new treatments.
