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Daraxonrasib nearly doubles pancreatic cancer survival
Daraxonrasib, a daily pill that blocks malfunctioning RAS proteins, nearly doubled median survival to 13 months in a 500-patient Phase III trial of advanced pancreatic cancer, outperforming standard c
STAT's ADA newsletter provides day‑2 conference recap
STAT’s ADA in 30 Seconds newsletter delivers a day‑2 recap of the American Diabetes Association annual conference. The full article and premium analysis are exclusive to STAT+ subscribers, who can sig
Retatrutide Linked to Arrhythmias, Cardio Risks
Eli Lilly presented new safety data for its next‑generation obesity drug, retatrutide, at the American Diabetes Association meeting. In the TRANSCEND‑T2D‑1 trial, 7 of 403 participants on retatrutide
GLP‑1 Weight‑Loss Drugs Linked to 30% Lower Breast
A study of over 110,000 women found that users of GLP‑1 medications—including Ozempic, Wegovy, Mounjaro, and Zepbound—had about a 30% lower risk of developing breast cancer. The observational findings
STAT+: Detailed data show Pfizer’s monthly obesity drug continues to show potential
Pfizer’s obesity drug berobenatide, acquired from Metsera, was tested in the VESPER‑3 mid‑stage trial where patients switched from weekly to higher monthly doses. Those who remained on treatment lost
The supplements older adults actually need and the ones they don't
Older adults are increasingly using dietary supplements, yet many offer little benefit unless a specific deficiency exists. The article highlights that low vitamin B12, vitamin D, protein, and folate
JAMA Review Finds Diagnostic Interviews Less Reliable
A new JAMA Network Open review of diagnostic interviews from February 2024 to September 2025 found that test‑retest reliability varies across mental‑health conditions, with substance‑use disorders—esp
Free‑living amoebae pose health risk, study warns
Scientists warn that free‑living amoebae, microbes found in water and soil, are an underappreciated public‑health risk capable of causing deadly infections and shielding other pathogens. The brain‑eat
First Opinion Podcast Explores Amish Views on Vaccines
The First Opinion Podcast hosts a conversation with medical researchers Braxton Mitchell and Cory Anderson about the Amish, public health, and vaccine attitudes. The hosts explain that the Amish are a
Removing ‘invisibility cloaks’ and safely skipping chemo: new weapons in war on cancer shared at US conference
At a US cancer conference, researchers presented new oral and combination therapies that overcome tumor immune evasion and improve outcomes. The tablet GRWD5769 plus cemiplimab shrank tumours in 26 of
STAT+: Newer GLP-1s, pushback on research cuts, and a protest
STAT+ launches its first ADA in 30 Seconds newsletter from the American Diabetes Association’s annual conference in New Orleans. Editor Elizabeth Cooney introduces the briefing, highlighting upcoming
Columbia Study Shows Base Editing Edits Embryos Safely
Recent research shows CRISPR base editing can modify healthy human embryos without the unwanted mutations that plagued earlier CRISPR‑Cas9 approaches. A Columbia study led by Dieter Egli achieved prec
SETI Updates Alien Signal Verification Protocols
The International Academy of Astronautics has published updated protocols for how SETI researchers should verify, announce, and manage potential signals from intelligent alien civilizations, replacing
Launch HN: General Instinct (YC P26) – Frontier models on edge devices
General Instinct, a robotics‑focused startup, open‑sourced its InstinctRazor toolkit and demonstrated that the 245 GB BF16 MoE model Qwen3.5‑122B‑A10B can be compressed to a 48 GiB GGUF while preservi
Cambridge AI Coronavirus Vaccine Passes Human Trial
Scientists at the University of Cambridge and spinout DIOSynVax have completed a Phase I trial of an AI‑designed universal coronavirus vaccine in 39 healthy volunteers. The vaccine was safe, well tole
Genetic variants cause 10% resistance to Ozempic
A Stanford‑led international study identified genetic variants that render about 10% of people less responsive to GLP‑1 receptor agonists such as Ozempic. Carriers of these variants showed poorer bloo
Japan Team Inserts Rat Chromosome into Mouse Embryos
Japanese researchers at Yamanashi University have inserted a deep‑frozen rat chromosome into mouse embryos, producing chimeric mice and demonstrating a new way to study extinct‑animal genes in living
Feyi-Waboso in race to face Boks after facial surgery
England winger Immanuel Feyi‑Waboso had facial surgery after a jaw injury in Exeter’s win over Leicester, ruling him out of the club’s final Premiership match against Saracens. The game, a playoff‑dec
Collatz Conjecture Stumps Math for 90 Years
The Collatz conjecture, a deceptively simple number rule proposed by Lothar Collatz in the 1930s, has stumped mathematicians for nearly a century, with the strongest progress coming from Terence Tao i
Anglia Ruskin study finds collagen boosts skin, joints
The largest meta‑analysis of collagen supplements, led by Anglia Ruskin University, pooled data from 16 systematic reviews, 113 randomized trials and nearly 8,000 participants. It found that regular c
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