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Barcelona DNA therapy slashes LDL 50% without statins
Researchers from the University of Barcelona, in collaboration with the University of Oregon, have engineered DNA‑based polypurine hairpins that silence the cholesterol‑raising protein PCSK9, slashing
Julia Vitarello starts biotech to scale bespoke drugs
Julia Vitarello, whose daughter Mila received a bespoke therapy eight years ago, is launching a new biotech to mass‑produce personalized medicines after her prior venture, EveryONE Medicines, folded d
UK Biobank has my data, but I’m not worried. I know the benefits are too great to consider pulling out | Polly Toynbee
A rogue listing of UK Biobank data on Alibaba sparked alarm, but Chinese authorities quickly removed the non‑identifiable data and only a few participants withdrew. The episode underscores the robustn
University of Toulouse Finds HSL in Fat Cell Nucleus
Researchers at the University of Toulouse discovered that hormone‑sensitive lipase (HSL) isn’t just a fat‑burning enzyme on lipid droplets—it also works inside the nucleus of fat cells to preserve hea
DoD to launch MDMA therapy trial for 186 soldiers
The U.S. Department of Defense will launch two MDMA‑assisted therapy trials next year, treating 186 active‑duty personnel with PTSD in an effort to evaluate the drug’s potential to aid recovery and ma
Veradermics Trial Data and Servier’s Day One Deal
STAT’s weekly Readout Loud podcast featured Veradermics CEO Reid Waldman unveiling promising hair‑loss trial data, while Servier Pharmaceuticals CEO David Lee outlined the firm’s acquisition of Day On
Harvard AI Outperforms Doctors in ER Triage Study
A Harvard study published in Science found OpenAI's o1 reasoning model outperformed human doctors at emergency room diagnosis and treatment planning, though researchers stressed AI would augment rathe
Trump Slashes Science Funding, Dismisses NSF Board
Trump’s push to halve federal science funding and his recent dismissal of the National Science Foundation board have been softened by a modest budget increase for research but cuts to the CDC, sparkin
Hinge Gets FDA Clearance for Migraine Device
Hinge has secured FDA clearance for a new migraine treatment device, marking the company's entry into the medical‑device arena. The approval expands Hinge's health‑tech portfolio and offers patients a
Obscore AI Spots Disease Risk in Overweight Patients
UK researchers have built an AI tool called Obscore that could reshape how the NHS rations weight-loss drugs, using personalized risk scores for obesity-related diseases rather than BMI cutoffs alone.
Blocking PTP1B Restores Memory, Clears Brain Plaques
Cold Spring Harbor Laboratory researchers showed that inhibiting the PTP1B protein improved learning and memory in Alzheimer's mouse models by rejuvenating exhausted brain immune cells that clear amyl
Aerobic Exercise Tops Other Workouts for Knee OA
A BMJ systematic review of 217 clinical trials involving 15,684 participants found aerobic exercises like walking, cycling, and swimming outperformed every other exercise type for reducing knee osteoa
Hidden Stripe Map in Nose Reveals Smell's Organization
A Harvard Medical School study has produced the first detailed map of smell receptor organization, revealing that neurons in mice noses are arranged in precise horizontal stripes — overturning the lon
3D Imaging Reveals How T Cells Target Cancer
Scientists have captured 3D images of cytotoxic T cells destroying cancer cells at nanometer resolution, revealing new details about how these immune cells target threats without harming healthy tissu
10‑Year Trial Finds Meniscus Surgery Worsens Knee OA
A decade‑long Finnish trial found that partial meniscectomy for meniscus tears offers no benefit and may accelerate osteoarthritis, while leading surgeons now urge longer conservative treatment. The r
Dave Hone disputes pack hunting, cites social evidence
Palaeontologist Dave Hone argues that dinosaurs likely did not hunt in coordinated packs, but many species displayed complex social behaviors such as juvenile groupings, intraspecific combat, and sexu
Friendly AI chatbots more likely to support conspiracy theories, study finds
An Oxford study reveals that tuning AI chatbots for a friendlier tone cuts factual accuracy by up to 30% and makes them 40% more likely to endorse conspiracy theories. This trade‑off collides with ind
Apple MacBook Neo Uses Binned A18 Pro Chips With Disabled GPU Core
Apple's new budget MacBook Neo appears to use binned A18 Pro chips salvaged from production flaws, with one GPU core disabled. Experts say the common industry practice is invisible to users, as error-
STAT+: A patent win for Pfizer and BridgeBio
Italian pharma Chiesi is expanding its rare‑disease portfolio with a $1.9 billion acquisition of KalVista, adding the hereditary angioedema pill Ekterly. At the same time, the FDA is piloting real‑tim
AstraZeneca Pledges £300m to UK in Reversal
AstraZeneca has pledged £300m to its UK operations, unfreezing a paused Cambridge expansion and funding a new lab in Macclesfield, in a reversal the prime minister tied to last year's UK-US drug prici
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