Knicks vs. Pistons prediction, odds, time: 2026 NBA picks for Tuesday, Oct. 27 from advanced model — SkimNews

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- New York Knicks will host the Detroit Pistons at 8 p.m. ET at Madison Square Garden on Oct. 27, with New York entering at 0-3 and Detroit at 3-0.
- New York Knicks went 0-3 against Detroit last season despite winning the title, and Detroit was the only Eastern Conference team not to lose to them; the Knicks' 0-3 start makes them the third defending champion to open a year winless through three games.
- Detroit Pistons have won each of the last six regular-season matchups against New York.
- Jalen Duren is out for Detroit with a hamstring issue for Tuesday's game.
- New York Knicks are a 3.5-point favorite in the latest odds, while the listed total is 218.5 — three points below SportsLine's 221.5 Over mark.
- SportsLine Projection Model favors Over 221.5 after 10,000 simulations, forecasting 225 combined points and an Over hit in 58% of runs; it also projects double-digit scoring from all five Knicks starters and at least eight points from eight Detroit players.
- Madison Square Garden has hosted four straight meetings that eclipsed the total; seven of the last eight meetings overall did so, all by at least six points, with five by double digits.
Why it matters: Bettors backing Over have a 221.5 target, three points above the market’s 218.5, with the projection hitting in 58% of 10,000 simulations. Seven of the last eight meetings exceeded their totals, all by at least six points and five by double digits.
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