Notre Dame vs. Stanford prediction, odds, time: Week 6 college football picks by proven model — SkimNews

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- No. 3 Notre Dame (5-0) hosts Stanford (2-3) at 3:30 p.m. ET Saturday at Notre Dame Stadium for the Legends Trophy, installed as a 39.5-point favorite with the over/under at 54.5.
- Stanford is coming off its worst loss in six decades, a 57-3 defeat at Wake Forest, and has allowed 35, 45, and 57 points in its three losses this season.
- Notre Dame is averaging 41.2 points per game while allowing just 11.8, with a defense that allows the fewest yards in the nation; the Irish have won the last three meetings in this series by at least 49 points each.
- CJ Carr has passed for 1,197 yards with 13 touchdowns and just one interception through five games for the unbeaten Irish.
- The SportsLine projection model, running 10,000 simulations per game, projects 56 total points and rates the Over 54.5 as a value play 52% of the time, while also flagging one side of the spread hitting over 50% of simulations.
Why it matters: Bettors leaning on SportsLine's model — which entered Week 6 on a 40-35 run on top-rated college football picks — get a quantifiable lean: the Over hits at a 52% modeled rate, and the Irish are giving up double digits in four of five games despite the nation's No. 1 defense, undermining the case for backers laying 39.5.
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