Prisco Week 1 NFL Picks: Mahomes ACL Return Headlines Slate — SkimNews
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- Pete Prisco picks the Seahawks (-3) to beat the Patriots 26-14 in Wednesday's NBC opener, a rematch of the February Super Bowl where Seattle's defense again dominates a New England offense that 'didn't play well in the postseason'
- Prisco forecasts the Rams (-3.5) to edge the 49ers 28-27 in Thursday's historic Australia game on Netflix, noting both rosters are star-heavy and their recent meetings have been 'good, close games'
- Aaron Rodgers starts what Prisco calls his 'final season' for the Steelers (-3.5) against a Falcons team that names Tua Tagovailoa as its starter and is missing two top pass rushers; Prisco picks Pittsburgh 27-17
- Patrick Mahomes makes his first start since tearing his ACL on Monday night against Denver's elite defense, with Prisco backing the Chiefs (-2.5) to win it late at home, 20-17
- Josh Allen and the Bills are -1.5 at Houston, where they've lost six straight meetings; Prisco breaks the streak with a 23-20 pick, betting Buffalo will attack C.J. Stroud into turnovers
- Kirk Cousins starts at home for the Raiders (-3.5) against a Dolphins team giving Malik Willis his first start, with Prisco picking Las Vegas 21-17 in a close one
- Deshaun Watson starts at QB for the Browns at Jacksonville, where the Jaguars are favored by 8.5; Prisco projects a 30-13 Jaguars blowout behind Trevor Lawrence's passing game
Why it matters: The full 16-game Week 1 slate is anchored by three high-stakes narrative games: the Seahawks-Patriots Super Bowl rematch on NBC, Thursday's Australia debut between the Rams and 49ers, and Patrick Mahomes' first game back from a torn ACL on Monday night against Denver.
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