Oklahoma vs. Michigan prediction, odds, time: 2026 Week 2 college football picks by proven model — SkimNews

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- Michigan hosts Oklahoma at noon ET Saturday at Michigan Stadium in Ann Arbor for a Week 2 cross-conference matchup before Big Ten and SEC play begins for each side.
- Oklahoma is a 4.5-point road favorite with the over/under at 43.5 (down 2 points from the opener), after bookmakers flipped the Sooners from slight underdogs following their Week 1 performance.
- Michigan escaped with a 13-12 Hail Mary win over Western Michigan in Week 1, while Oklahoma shut out UTEP 51-0, allowing zero points even in garbage time and registering just 25 combined total points in the Wolverines' game.
- SportsLine's model, which simulates every FBS game 10,000 times and is on a 33-20 run on top-rated CFB money-line picks since 2024 (upgraded for 2026 to factor in the transfer portal), projects the Under at 43.5 — forecasting 42 combined points and hitting 51% of the time.
- SportsLine's model also identifies one side of the spread hitting well over 60% of the time, though that specific pick is locked behind SportsLine.
Why it matters: Bookmakers moved the line against Michigan after its shaky Week 1 outing, flipping Oklahoma from a slight underdog to a 4.5-point road favorite despite the game being played in Ann Arbor. The model's Under projection — driven by two dominant Week 1 defenses — gives bettors a data-backed lean on the total, while the spread pick remains gated behind SportsLine's paywall.
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