Iowa State vs. BYU prediction, odds, time: Week 6 college football Friday picks from proven model — SkimNews

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- BYU (4-0, 2-0 Big 12) is a 10.5-point favorite over Iowa State (3-2, 1-1 Big 12) for Friday's 10:15 p.m. ET kickoff at LaVell Edwards Stadium in Provo
- The SportsLine Projection Model simulated the game 10,000 times and projects 52 combined points, making the Over 45.5 its A-rated pick at 63% value
- BYU's money line sits at -426 (risk $426 to win $100), and the Cougars have outscored opponents 149-57 this season while going 2-0 at home
- Iowa State QB Jaylen Raynor has completed 58% of passes for 903 yards with 6 TDs and 4 INTs; Iowa State is 0-2 against ranked opponents and 0-1 on the road
- BYU QB Bear Bachmeier has completed 64% of passes for 704 yards, 6 TDs and 1 INT, and added 130 rush yards and 4 rush TDs on 27 carries
- Iowa State leads the all-time series 5-1, but BYU won last year's meeting in Iowa; SportsLine says one side of the spread hits over 50% of simulations
- The model entered Week 6 on a 40-35 run on top-rated college football picks
Why it matters: The 10.5-point spread makes this BYU's most significant home test of the unbeaten season. Iowa State enters as a proven road-test flip side: it is 0-1 on the road and 0-2 vs. ranked opponents, while BYU QB Bachmeier's 10 total touchdowns give the Cougars a dual-thread edge the model is pricing into its Over projection.
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