'Monday Night Football' prediction, odds, spread, time: Rams vs. Bills picks from expert on 28-10 roll — SkimNews
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- Los Angeles Rams (2-2) host the Buffalo Bills (3-1) at SoFi Stadium in Inglewood, Calif., on Monday Night Football with kickoff set for 8:15 p.m. ET.
- Los Angeles is a 3.5-point favorite with the over/under at 54.5; the Rams rank third in the NFC West while the Bills lead the AFC East and have outscored opponents 127-107 this season.
- Larry Hartstein is leaning Over 54.5, citing the Rams' healthy playmakers including Puka Nacua, who caught 9 passes for 125 yards on 12 targets in last week's 24-20 win at Philadelphia.
- Aaron Donald (back) carries no injury designation after missing the Rams' last two games, while Bills wide receiver D.J. Moore (shoulder) is questionable.
- Josh Allen is completing 66.4% of his passes for 1,039 yards, 6 touchdowns and 3 interceptions through four games, adding 33 rushes for 118 yards and 7 rushing touchdowns.
- Hartstein enters on a 28-10 ATS run (+1701) across his last 38 picks involving the Rams and went 50-37 ATS (57.5%) in the 2025 NFL season.
- The Bills and Rams combined for 86 points in their 2024 meeting, and the Over has hit in four of the last six head-to-head matchups.
Why it matters: Los Angeles is a 3.5-point home favorite despite a 2-2 record against a 3-1 Buffalo team, and Hartstein's 28-10 ATS run on Rams-related picks — plus the Over hitting in four of the last six head-to-head meetings — gives his Over 54.5 lean a stated track record to argue from, with Aaron Donald active and Nacua drawing 12 targets last week.
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