College football odds, picks, predictions for Week 4, 2026: Computer likes Colorado, USC — SkimNews
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- SportsLine's computer model locked in picks for every Week 4 FBS game by simulating each matchup 10,000 times, and sits at a profitable 22-19 on top-rated college football picks this season
- Colorado is picked to cover as a 10-point underdog at Baylor in a noon ET kickoff, with the Buffs going 11-5-2 ATS after a loss under Deion Sanders — a 69% cover rate that ranks 10th-best in FBS since his first season in 2023
- Baylor is 0-6 ATS after a win dating back to 2025, making the Bears the model-cited worst team in college football at handling success against the spread
- USC is picked to cover as a 3-point home underdog versus Oregon at 7:30 p.m. ET, with QB Jayden Maiava sporting an 11-1 home record and projected to outpace Oregon QB Dante Moore in yards, touchdowns and interceptions
- Oregon has struggled against FBS competition this season, edging Boise State by a touchdown as a 25.5-point favorite and losing outright to Oklahoma State as a 24-point favorite
- Week 4 marks the official kickoff of conference play, headlined by Texas at Tennessee (+4.5), Michigan vs. Iowa (+5.5), Oklahoma at Georgia (-14), Illinois at Ohio State (-27.5), and South Carolina at Alabama (-12.5)
Why it matters: Bettors riding the SportsLine model are up on a 22-19 run through the early season, and Week 4's conference-openers give the model concentrated spots where it has identified specific ATS trends — most notably Colorado's 69% bounce-back cover rate under Deion Sanders and Baylor's documented 0-6 ATS skid coming off wins since 2025.
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