AP503 Strengthens Mouse Bones by Activating GPR133 — SkimNews
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- AP503 significantly increased bone strength in both healthy and osteoporotic mice by activating GPR133.
- GPR133 activation encouraged osteoblast activity while reducing osteoclast activity, shifting bone remodeling toward stronger, more durable bone.
- Ines Liebscher reported that mice with genetically impaired GPR133 developed early bone-density loss resembling osteoporosis.
- AP503 also strengthened skeletal muscle in an earlier Leipzig University study, adding a muscle-strengthening dimension to the bone findings.
- Leipzig University researchers are pursuing follow-up projects to understand GPR133’s wider functions and investigate whether AP503 has applications in other diseases.
Why it matters: The finding gives researchers a defined target for a disease affecting six million people in Germany, most of them women: AP503 strengthened bones in healthy and osteoporotic mice, and earlier work found stronger skeletal muscle. The result remains mouse research rather than a demonstrated human treatment.
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