Indiana vs. North Texas prediction, odds, time: Week 1 college football picks from proven model — SkimNews

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- Indiana opens its CFP title defense Saturday at noon ET vs. North Texas at Memorial Stadium in Bloomington, listed as 40-point favorites with a 56.5 over/under in the latest odds.
- North Texas went 12-2 in 2025, a program record for wins, under new coach Neal Brown — formerly of Troy and West Virginia — who replaced Eric Morris after Morris left for Oklahoma State.
- The SportsLine model, which simulated the matchup 10,000 times and is on a 32-19 run on top-rated CFB money-line picks since 2024, is recommending the Over on 56.5.
- North Texas led FBS in points per game, yards per game, and offensive touchdowns last season, with the Over hitting in 71% of its games (10-4).
- The model projects 60 combined points, with the Over hitting 58% of the time; the last meeting between these teams saw 73 total points.
- Curt Cignetti's Hoosiers are 27-2 under him entering his third year, with the Over going 18-11 (62.1%) since he took over in 2024.
Why it matters: Saturday's opener is the first test of Indiana's title-defense spread (40 points) and total (56.5). The model sees points baked into both offenses — North Texas led FBS in scoring and yards last year — and lands on a 60-point projection that gives bettors a data-grounded Over lean.
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