Ole Miss vs. Louisville prediction, odds, time: 2026 Week 1 college football Sunday picks by proven model — SkimNews
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- Ole Miss and Louisville meet Sunday at 7:30 p.m. ET at Nashville's Nissan Stadium as the only ranked-vs.-ranked matchup of Week 1, with No. 9 Ole Miss a 6.5-point favorite over No. 24 Louisville and the total set at 54.5
- Pete Golding enters his first full season as Ole Miss head coach after taking over during last year's College Football Playoff run when Lane Kiffin departed for LSU
- Trinidad Chambliss returns at quarterback for Ole Miss as a Heisman candidate, paired with running back Kewan Lacy in what the source calls arguably the nation's best backfield
- Jeff Brohm's Louisville has won at least nine games in all three of his seasons as head coach, with the Cardinals finishing top 40 in both scoring defense and total defense last year
- The SportsLine model, on a 32-19 run on top-rated CFB money-line picks since 2024 and upgraded to factor in the transfer portal for 2026, went Under 54.5 after projecting both teams under 30 points
- Louisville's defensive front, anchored by NFL prospects Clev Lubin and A.J. Green, is positioned to slow an Ole Miss attack that the model nevertheless projects as the Under value in 60% of simulations
Why it matters: The SportsLine model's 32-19 run on top-rated CFB money-line picks since 2024 now includes an Under 54.5 lean for the only ranked-vs.-ranked Week 1 matchup, with one spread side hitting in nearly 60% of 10,000 simulations. The model bets on Louisville's top-40 defense holding an Ole Miss attack led by Heisman candidate Trinidad Chambliss under 30 points.
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