Ole Miss vs. Louisville prediction, odds, time: 2026 Week 1 college football Sunday picks via proven model — SkimNews
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- Ole Miss and Louisville meet at 7:30 p.m. ET Sunday at Nissan Stadium in Nashville in the only ranked-on-ranked matchup on the Week 1 college football schedule
- The Rebels are 6.5-point favorites with a -255 money line (risk $255 to win $100), with the over/under set at 55.5 points
- Pete Golding takes charge of Ole Miss for his first full season after guiding the team during last year's College Football Playoff run, following Lane Kiffin's departure to LSU
- Trinidad Chambliss, a Heisman candidate quarterback, returns for Ole Miss alongside running back Kewan Lacy in what the source calls arguably the nation's best backfield
- Jeff Brohm's Louisville has won at least nine games in all three of his seasons and returns a top-40 scoring and total defense anchored by NFL prospects Clev Lubin and A.J. Green
- The SportsLine model, on a 32-19 run on top-rated CFB money-line picks since 2024, projects neither team scoring more than 30 points (combining for 49), rates the Under 55.5 an A-level pick hitting in 60% of simulations, and also has one side of the spread hitting nearly 60% of the time
Why it matters: Ole Miss is a 6.5-point favorite despite breaking in a new head coach, and the SportsLine model — upgraded for 2026 to factor in the transfer portal — gives the Under an A rating with 60% confidence, offering a quantified counterweight to the Chambliss Heisman hype. For bettors, the model's simultaneous 60% spread conviction creates a layered play in the week's marquee game.
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