Michigan vs. Oklahoma odds, picks, predictions: Betting preview, time for Week 2 college football matchup — SkimNews

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- Michigan narrowly defeated Western Michigan 13-12 in Week 1 on a controversial last-second play, a result that dropped them out of the AP Poll and raised doubts about quarterback Bryce Underwood's readiness
- Oklahoma routed UTEP 51-0 in its season opener, showcasing offensive strength and defensive continuity with six returning defensive starters from last year’s seventh-ranked scoring defense
- Bryce Underwood struggled significantly against Western Michigan, delivering an inconsistent performance that left head coach Kyle Wittingham unwilling to name him the long-term starter
- John Mateer enters as Oklahoma’s dynamic quarterback, currently +3500 in Heisman Trophy odds, anchoring an offense that aims to exploit Michigan’s shaky early-season form
- The SportsLine Projection Model simulates FBS games 10,000 times and projects Michigan to cover the 5.5-point spread at a 66% rate, despite the Wolverines’ unconvincing debut
- DraftKings lists Oklahoma as a 5.5-point favorite for the matchup at The Big House, with kickoff set for noon ET, and offers $200 in bonus bets for new bettors who place a $5+ wager
Why it matters: Michigan is a 5.5-point home underdog despite historical advantage at The Big House, a rare signal of market skepticism after a fluky win — if Oklahoma’s defense contains Underwood, it could derail Michigan’s season before conference play begins.
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