UCSF Study Finds Surface Src Kinase on Tumor Cells
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- Jim Wells and his UCSF team observed the Src kinase on the surface of malignant cells, a location normally confined inside cells.
- Science published the team's report, noting that surface Src was absent from healthy donor tissue.
- The discovery is highlighted as a potential new immunotherapy target for solid tumors.
- Kathleen Yates of the Broad Institute called the finding provocative but cautioned that its translational impact remains uncertain.
Why it matters: Researchers gain a novel surface protein to pursue for solid‑tumor immunotherapy, while patients could eventually benefit from new treatments; however, the clinical relevance remains uncertain, as experts note the translational impact is still an open question. The finding also underscores the need for further validation before therapeutic development can proceed.
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