Arginine Supplement Cuts Alzheimer’s Amyloid Buildup
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- Arginine blocks Aβ42 aggregation in vitro and reduces amyloid plaques and brain inflammation when given orally to AD mouse and fruit‑fly models.
- Kanako Fujii co‑author of the Neurochemistry International paper showed that oral arginine lowered toxic protein deposits and improved behavior in AppNL‑G‑F knock‑in mice.
- AppNL‑G‑F mouse model carrying three familial AD mutations showed a measurable drop in amyloid plaque levels after arginine treatment.
- Drosophila Arctic mutation model (E22G) exhibited reduced Aβ42 accumulation and better locomotor performance with arginine supplementation.
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