Week 3 College Football Odds: LSU at Ole Miss Headlines — SkimNews
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- LSU-Ole Miss headlines Week 3 as the lone top-10 matchup, with Lane Kiffin returning to Oxford to face his former team; LSU is a 3-point road favorite and the home team has won each of the last six meetings in the series.
- SportsLine's model simulates every FBS game 10,000 times, carries a 33-21 record on top-rated CFB money-line picks since 2024, and has been upgraded for 2026 to better factor in transfer portal movement.
- South Carolina is a 3.5-point home favorite over Mississippi State, with QB LaNorris Sellers posting 270 passing yards and 3 TDs in Week 1 before adding 119 rushing yards and a score in Week 2; the Gamecocks have won 8 of the last 9 meetings and SC's defense has allowed just one touchdown all season.
- Notre Dame is favored by 29.5 points at home over Michigan State, riding a 12-game winning streak where every victory came by double digits — the longest such streak by any team since 2019 — while MSU has lost 12 straight against AP top-5 teams by an average margin of 29.3 points.
- Other Week 3 spreads include No. 2 Georgia laying 24.5 at Arkansas, No. 10 Alabama giving 20.5 against Florida State, No. 12 USC favored by 24.5 at Rutgers, and top-ranked Texas as a 30-point favorite over UTSA.
Why it matters: SportsLine's model carries a documented 33-21 record on top-rated CFB money-line picks since 2024, now upgraded for 2026 to factor in transfer portal movement — giving bettors actionable projections for every FBS Week 3 game from 30-point mismatches to tight conference clashes like LSU-Ole Miss.
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