Michigan vs. Indiana odds, picks, predictions, line, spread: Saturday college football betting preview — SkimNews

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- Michigan hosted No. 6 Indiana in a Big Ten clash at 'The Big House' with a noon ET kickoff, entering 4-2 overall and 1-2 in conference play
- Indiana entered the game 6-1 overall and 3-1 in Big Ten action after a 19-15 home loss to Ohio State, remaining in strong playoff contention
- Michigan rushed for 211 yards and three touchdowns against Penn State, highlighting a ground game that could challenge Indiana's defensive strength
- Indiana managed just 138 rushing yards on 51 carries over its previous two games, raising questions about its ability to control the line of scrimmage
- Josh Hoover has thrown 18 touchdown passes without an interception this season, giving Indiana a significant edge in quarterback play
- Tommy Carr and Bryce Underwood split quarterback reps for Michigan the prior week, with no definitive starter named ahead of the Indiana game
- SportsLine Projection Model predicts Indiana covers the -7 spread in 64% of simulations, backing the Hoosiers to win and exceed betting expectations
Why it matters: Indiana’s unblemished quarterback record and playoff aspirations clash with Michigan’s defensive strength and home-field advantage, making the line of scrimmage the decisive factor; a Hoosiers win would mark only their third-ever back-to-back victories in the 73-game series and reshape Big Ten title race dynamics.
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