Indiana vs. Nebraska prediction, odds, time: Week 6 college football picks by proven model — SkimNews
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- Indiana (5-0, ranked No. 6) travels to Lincoln for a noon ET kickoff against Nebraska (5-0) at Tom Osborne Field, with the Hoosiers installed as 7.5-point road favorites and -325 on the money line.
- Josh Hoover, a TCU transfer, leads an Indiana offense averaging 44.2 points per game that has committed just one turnover all season — the second-fewest in the country.
- Nebraska averages 43.6 points per game behind quarterback Anthony Colandrea, the 2025 Mountain West Offensive Player of the Year, with 30 touchdowns scored this season (ninth-most nationally).
- Indiana vs. Nebraska odds show an over/under of 47.5, a 3-point drop since the line opened, reflecting the top-10 scoring offenses on both sides.
- SportsLine's Projection Model, which entered Week 6 on a 40-35 run on top-rated college football picks, simulated the matchup 10,000 times and projects 50 combined points, making the Over the value play.
Why it matters: The model has been profitable on CFB picks this season (40-35 run), so its Over projection carries documented weight — and with Indiana (-325 ML) priced as a heavy road favorite, the 7.5-point spread means the market is far less uncertain about the winner than it is about whether both top-10 scoring offenses can keep pace against each other in a 47.5-point total.
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