Menin Loss Drives Mouse Aging; D‑Serine Boosts Memory
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- Menin levels drop sharply in the ventromedial hypothalamus of aging mice, triggering inflammation, memory loss, bone thinning and a shorter lifespan.
- D‑Serine supplementation restored cognition in mice with low Menin, showing a simple amino‑acid boost can reverse brain decline.
- Lige Leng and his team at Xiamen University engineered mice with reduced Menin, which caused thinning skin, bone loss, balance defects, memory problems and reduced longevity.
Why it matters: Biotech firms gain a clear drug target, as the Menin‑D‑Serine pathway reversed several aging signs in mice, reshaping the market for age‑related treatments.
