2026 Week 2 NFL odds, betting lines, spreads, start times: Get Week 2 NFL picks, predictions for every game — SkimNews
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- Buffalo Bills are 5.5-point home favorites over the Detroit Lions on Thursday Night Football, with the over/under at a slate-high 54.5 points (up one from the opener) after both teams won their Week 1 openers by a combined score
- San Francisco 49ers are the biggest ATS favorite of Week 2 at -13.5 points hosting the Miami Dolphins, whose Week 1 upset over the Rams in Australia now faces a steep line; the over has hit in each of the past five meetings between the teams
- Seattle Seahawks are still 4.5-point road favorites at Arizona despite losing starting QB Sam Darnold to a soft-tissue injury in their Week 1 win, leaving backup quarterback duties for the divisional matchup
- Chicago Bears are -5.5 at home over the Minnesota Vikings after a historic 59-point Week 1 outburst — Caleb Williams hit 72.9% of his passes for 269 yards and two touchdowns while D'Andre Swift added 124 rushing yards and three scores
- Philadelphia Eagles are 7-point road favorites at Tennessee with the lowest total on the board (39.5) after the Titans managed just 195 yards and 10 points in their Week 1 loss to the Jets
- Sportsbooks including DraftKings, FanDuel, BetMGM, Caesars, bet365, Hard Rock Bet, and Fanatics are offering a combined nearly $4,000 in bonus bets and promos for Week 2 NFL action, ranging from DraftKings' $200 after a $5 wager to BetMGM's up to $1,500
Why it matters: The 49ers' 13.5-point spread is the widest on the Week 2 board and signals how lopsided oddsmakers view that matchup, while the Eagles-Titans 39.5 total underscores expectations of a slog in Tennessee — together these lines shape where the public money and sharp action concentrate, with $4,000 in available sportsbook promos amplifying bettor incentive across all 16 games.
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