2026 Week 2 NFL odds, betting lines, spreads, start times: Get Week 2 NFL picks, predictions for every game — SkimNews
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- NFL Week 2 schedule features 16 games with playoff implications, headlined by Thursday Night Football's Lions vs. Bills (-5.5), plus notable spreads like Vikings vs. Bears (-5.5), Commanders vs. Cowboys (-4.5), and Colts vs. Chiefs (-6.5)
- Buffalo Bills are 5.5-point home favorites over the Lions, with both teams coming off Week 1 thrillers — Detroit's 31-30 overtime win over New Orleans and Buffalo's 36-31 road victory at Houston
- Chicago Bears are 5.5-point home favorites over the Vikings after a historic 59-point Week 1 rout of Carolina, where Caleb Williams went 72.9% for 269 yards and two TDs while D'Andre Swift rushed for 124 yards and three scores
- Baltimore Ravens are 8.5-point road favorites at New Orleans following their 41-23 Week 1 win over Indianapolis, which featured Derrick Henry rushing for 144 yards and three touchdowns
- San Francisco 49ers sit as the biggest Week 2 ATS favorite at -13.5 over Miami after pulling off an upset of the Rams in Australia, while the Eagles vs. Titans game carries the lowest total on the board at 39.5 points
- Seattle Seahawks are 4.5-point road favorites at Arizona despite losing starting QB Sam Darnold to a soft-tissue injury in their Week 1 win over New England
- DraftKings, FanDuel, BetMGM, Caesars, Fanatics, and bet365 are offering a combined nearly $4,000 in bonus bets for new users wagering on the Week 2 NFL slate
Why it matters: The Week 2 card features several heavy lines — the 49ers at -13.5 over Miami is the largest ATS favorite of the week — giving sharp bettors the kind of inflated spreads that historically attract steam. With Sam Darnold sidelined yet Seattle still favored on the road, the injury storyline will likely push that line closer to kickoff, creating a clear market-disadvantage for early-bird bettors.
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