Prisco's Week 6 NFL Picks: Bucs Upset Steelers, Purdy MVP Case — SkimNews
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- Pete Prisco bounced back from a rough Week 4 with a 10-4-1 straight-up and 9-6-1 against-the-spread performance in Week 5, bringing his season records to 48-30-1 straight up and 34-43-2 ATS.
- The Buccaneers (+3) will upset the Steelers 26-21 at home, per Prisco, who cited Bucky Irving's running game and an improved Tampa Bay defense that limited opponents last week.
- Brock Purdy continues building his MVP case as Prisco picks the 49ers (-7.5) to cruise past the visiting Commanders 30-21, calling San Francisco "the league's best team right now."
- Patrick Mahomes and the undefeated Chiefs (-8.5) host the 0-5 Chargers, with Prisco highlighting Andy Reid's strong post-bye record in a projected 28-21 Kansas City win.
- The Rams (-13.5) are double-digit favorites over the Cardinals despite sitting at 2-3, with Prisco labeling them the disappointing "Dream Team" and projecting a 35-20 win powered by Matt Stafford.
- The Seahawks (-3) will beat the Broncos 23-17 on Thursday night, with Prisco citing Denver's offensive struggles even after Sean Payton took over play-calling duties.
- The Eagles (-1.5) host the Panthers coming off a London loss and mounting injuries, but Prisco picks Philadelphia 23-20 in a "desperation" win behind their defense.
Why it matters: Prisco's ATS record sits at 34-43-2 — still below .500 after a slow climb back from a brutal Week 3 — meaning bettors following his picks have lost money this season despite his 48-30-1 straight-up accuracy. His Bucs upset call and Purdy MVP framing will draw the most attention from fantasy players and NFL bettors tracking Week 6 line movement.
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