NFL Week 6 Odds, Picks: Chiefs-Cardinals, Cowboys-Packers — SkimNews

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- The NFL's Week 6 slate includes 12 Sunday games plus a Monday night matchup, with four teams on bye, four games carrying over/unders of more than 50 points, and a schedule shortened from the typical 16 games.
- The Kansas City Chiefs (4-0) are 8.5-point home favorites over the visiting Cardinals (0-5) with an over/under of 42.5, while the Chargers will play without safety Derwin James Jr. (hamstring), wide receiver Tre Harris (hamstring), and tackle Joe Alt (neck).
- The Green Bay Packers, coming off a 31-7 rout of the Bears, are 1.5-point home favorites over Dallas on Sunday Night Football (over/under 52.5); the Cowboys fell 24-16 to Tampa Bay on Thursday Night Football.
- The Philadelphia Eagles will be without starting quarterback Jalen Hurts (blood clot) for Sunday's home game against the Panthers, who are getting 3.5 points; Carolina's Bryce Young is averaging 317 passing yards per game after a 32-26 win over Detroit.
- The Jacksonville Jaguars (4-1) are 3-point favorites over the Texans (1-4) in Sunday's Wembley Stadium game in London, riding Cam Little's walk-off 57-yard field goal that beat Philadelphia 19-17 last week.
- Pittsburgh Steelers quarterback Aaron Rodgers moved to third all-time in passing touchdowns (580 including playoffs) after throwing three scores in a 34-22 win over Indianapolis; the 3-2 Steelers visit the 1-4 Buccaneers on Sunday.
- Online sportsbooks including DraftKings ($200 bonus), FanDuel ($350), BetMGM ($1,500), bet365, Caesars, Hard Rock Bet, and Fanatics are offering more than $3,000 in combined sign-up bonuses, with legal online betting now available in 30-plus states plus Washington D.C. and Puerto Rico.
Why it matters: Week 6 concentrates marquee storylines — the unbeaten Chiefs hosting one of three winless teams, Hurts sidelined by a notable injury, and Rodgers climbing the all-time passing list — into a 12-game slate where four totals exceed 50 points after the Over hit in both 50-plus games last week. For bettors, sportsbooks are aggressively competing for sign-ups with combined bonuses exceeding $3,000 across at least seven major platforms, making this one of the more promo-loaded slates of the young season.
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