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STAT+: ARPA-H launches $160 million effort to develop custom gene editing drugs
ARPA-H announced Thursday it will spend up to $160 million on THRIVE, a new program backing seven teams developing custom gene editing treatments for rare diseases across multiple organ systems, with
Thermodynamics rebuilt on gauge theory math
A researcher at the London School of Economics is rebuilding the 200-year-old theory of thermodynamics using the mathematics of gauge theory, a framework typically used in quantum field theory, potent
AstraZeneca, Ionis heart drug Wainua fails pivotal trial
AstraZeneca and Ionis Pharmaceuticals' partnered heart drug Wainua failed to outperform placebo in a pivotal ATTR-CM trial, hitting both companies' stocks in premarket trading on Thursday.
Seniors Lead Cannabis Adoption; Doctors Trail Behind
In an opinion piece, Dr. Peter Grinspoon of Massachusetts General Hospital argues that seniors are now the fastest-growing group of medical cannabis patients but most physicians lack the training to c
Obesity Disease Label Serves Drugmakers, Op-Ed Argues
An opinion piece argues that classifying obesity as a disease primarily serves pharmaceutical companies like Eli Lilly and Novo Nordisk, redirecting attention from social and environmental interventio
STAT+: The quest to save Grace — and clear the way for rare disease patients everywhere
Matt Wilsey has spent a decade and $70 million developing a gene therapy for his 15-year-old daughter Grace's ultra-rare NGLY1 deficiency; with 10 patients treated and his company out of cash, he is n
Vitamin A Signals Convert Blue Cones in Fetal Eye
Johns Hopkins researchers found that blue cone cells in the fetal eye convert into red and green cones—rather than migrating outward—under the influence of vitamin A-derived retinoic acid and thyroid
Semaglutide Dosing Errors Fueled Poison Call Spike
Research from the University of Texas at San Antonio links a dramatic surge in U.S. poison control calls about semaglutide (Ozempic and Wegovy) to the drug's 2021 FDA approval for weight management, w
Harvard scientists turn a silicon chip into a DNA writing machine
Harvard researchers have built a silicon chip that simultaneously synthesizes 64 distinct DNA sequences using electricity-triggered enzymatic reactions in water, potentially replacing the hazardous or
Silica nanoparticles cured aggressive prostate cancer in mice
Weill Cornell researchers engineered ultrasmall silica nanoparticles that selectively killed aggressive prostate cancer cells and reactivated the immune system in mice, producing complete remissions w
A country that made huge progress on measles now reports 120,000 cases
Bangladesh is battling a devastating measles outbreak with over 120,000 suspected and confirmed cases and nearly 750 deaths—mostly children—since mid-March, reversing years of progress toward eliminat
Bacterial 'docking domains' unlock cancer drug engineering
University of Warwick researchers have decoded how bacterial enzymes cooperate to produce multiple variants of powerful anti-cancer drugs, identifying molecular 'docking domains' as the connectors beh
MenB Vaccine Fails to Prevent Gonorrhoea in Major Trial
A major Australian trial has found the MenB vaccine offers no protection against gonorrhoea in men, undermining earlier studies that had prompted the NHS to begin offering the jab to gay and bisexual
RFK Jr. plans Covid vaccine injury list for compensation
Health Secretary Robert F. Kennedy Jr. is preparing a federal list of injuries presumed to be caused by Covid-19 vaccines, creating a new pathway for claimants to seek government compensation.
Healey Summons Mass General Brigham, Nurses to State House
Governor Maura Healey summoned Mass General Brigham and its striking nurses to the State House for a late-afternoon meeting aimed at ending the largest nurses strike in Massachusetts history, the firs
Drug Softens Ovaries, Doubles Conception in Older Rats
A drug that softens aging ovaries more than doubled conception rates and quintupled litter sizes in older rats and mice in a study led by Chinese researchers, raising hopes that a similar intervention
Trump Officials Push Pharma to Onshore Generic Drug Production
Trump administration officials, including Secretary of State Marco Rubio and HHS Secretary Robert F. Kennedy Jr., met privately with pharmaceutical leaders to push for bringing production of 86 essent
STAT+: Prime Medicine claims victory in dispute over gene-editing technology with Beam Therapeutics
Prime Medicine won an arbitration ruling against Beam Therapeutics, clearing it to proceed with a clinical trial for a gene-editing drug targeting the rare liver disease alpha-1 antitrypsin deficiency
STAT+: Pharmalittle: We’re reading about a Vera kidney drug approval, a U.K. Enhertu pricing deal, and more
Two pharma developments are making headlines: the FDA approved Vera Therapeutics' $425,000-per-year kidney drug Trutakna for IgA nephropathy, while U.K. officials near a pricing deal with AstraZeneca
Schrödinger's 1944 'What Is Life?' still shapes biophysics
More than 80 years after its 1944 publication, Erwin Schrödinger's 'What Is Life?' continues to shape biophysics research with its physicist's framing of life, including the concept of 'negative entro
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