Week 6 NFL odds, picks, predictions: Computer model backs Patriots and Cardinals — SkimNews
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- SportsLine's computer model, which simulates every NFL game 10,000 times, is up more than $5,000 for $100 players on top-rated NFL picks since inception, entering Week 6 of the 2026 season on a 57-46 run dating back to 2024.
- The Patriots (-7, O/U 43.5) are the model's strongest Week 6 pick to cover at home vs the Jets in a Sunday 1 p.m. ET kickoff, following back-to-back wins over Buffalo and Vegas and a 371-yard passing day against a Raiders defense that had allowed just 202.8 passing yards through four games.
- New England has covered in three straight matchups with the Jets, with a 16-point average margin of victory, while New York's 27th-ranked scoring offense tries to keep the spread within seven points.
- The Cardinals (+12.5, O/U 52.5) are picked to cover at the Rams in a 4:05 p.m. ET kickoff, riding an 11-5 ATS record as road underdogs since 2024 (2-0 this season) — a 69% cover rate ranked third-best in the league over that span.
- Arizona posted a season-high three passing scores this past Sunday and now faces a Rams team that is third-worst in the NFL with a minus-five turnover differential, playing on a short week.
- Half of Week 6's Sunday slate is divisional, including Ravens vs Browns (+4.5), Patriots vs Jets (+7), Rams vs Cardinals (+12.5) and Chiefs vs Chargers (+8.5), with four matchups carrying O/U totals of at least 50 and the Bills giving 5.5 points as the biggest road favorite at the Raiders.
Why it matters: For bettors weighing Week 6 cards, the SportsLine model is leaning on two divergent strengths: a Patriots team riding hot passing efficiency against a bottom-tier Jets offense, and Cardinals-as-road-dog trends that have cashed at a 69% clip since 2024. The model's track record — 57-46 on top-rated picks and $5,000-per-$100 returns since inception — is the selling point for anyone paying to see every locked-in pick across the 14-game slate.
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