Ole Miss vs. Vanderbilt odds, picks, predictions, start time: Betting preview for college football Week 6 — SkimNews
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- Ole Miss (3-1) faces Vanderbilt (3-2) in an SEC Week 6 matchup with a 3:30 p.m. ET kickoff Saturday, with Ole Miss listed as a 9.5-point favorite and the over/under set at 54.5.
- Ole Miss has won five consecutive meetings against Vanderbilt, including a 33-7 home victory in 2023, and is coming off a bye week following a 52-28 road loss at Florida in Week 4.
- Vanderbilt enters on back-to-back losses — 21-15 to Auburn and 38-14 to Georgia — and is 3-2 ATS in its last five games, having covered each of its last three, including its first two SEC contests.
- Ole Miss quarterback Trinidad Chambliss leads the SEC with 305.5 passing yards per game (1,222 yards, 8 TDs, 3 INTs on 102-of-144 passing) and has added 108 rushing yards and four touchdowns on 28 carries this season.
- Vanderbilt running back Sedrick Alexander paces the Commodores' ground game with 200 yards and four touchdowns on 45 rushing attempts, including 35 yards and a score on eight carries against Georgia.
- The pick is Vanderbilt +9.5, with the Commodores posting a 2-0 ATS record as underdogs and 1-0 ATS vs. ranked opponents, while SportsLine's model projects a 30-24 Ole Miss win — a 55% spread probability that exceeds the implied consensus of 51.5%.
Why it matters: For bettors, the 9.5-point spread looks soft: Vanderbilt has covered three straight and is 1-0 ATS against ranked teams this season, while SportsLine's 30-24 projection implies a six-point margin — well inside the number — giving the Vanderbilt +9.5 play a quantified edge over the 51.5% consensus implied probability on Ole Miss laying the points.
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