Wyoming vs. San Jose State prediction, odds, time: Week 6 college football Friday picks by proven model — SkimNews

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- San Jose State (3-2, 1-0 Mountain West) hosts Wyoming (2-3, 1-1) at CEFCU Stadium on Friday at 9 p.m. ET on CBS Sports Network, with SJSU a 4.5-point favorite and a -192 money line.
- SportsLine's Projection Model, after 10,000 simulations, is going Over the 42.5-point total and projects 45 combined points, pegging the Over as a 52% value.
- The locked spread pick hits well over 60% of the time in the model's sims but is gated behind SportsLine's paywall.
- Wyoming is coming off a 28-0 loss to North Dakota State and has covered the spread just once in five games this season, while SJSU is 3-2 ATS.
- SJSU's defense ranks 8th in the Mountain West in scoring, giving up 25 points per game, against a Wyoming offense that has struggled — creating the conditions the model is targeting.
Why it matters: Bettors get a quantifiable model lean (52% Over value, 60%+ on the locked spread side) from a SportsLine model on a 40-35 profitable run entering Week 6. With SJSU's defense allowing 25 points per game (8th in Mountain West) and Wyoming coming off a 28-0 shutout loss, the matchup offers exploitable pricing — but the sharpest data point (the spread pick) is paywalled.
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