Bills vs. Lions predictions, odds, spread, time: Week 2 'Thursday Night Football' picks from advanced model — SkimNews
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- Buffalo Bills make their Highmark Stadium regular-season debut under coach Joe Brady against the Detroit Lions on Thursday Night Football (8:15 p.m. ET) to open Week 2.
- Buffalo is a 5.5-point favorite, a 2.5-point shift from the opening line of Bills -3, with the total set at 54.5.
- Jahmyr Gibbs powered Detroit's 31-30 overtime win over the Saints with 29 carries for 156 yards and two touchdowns, plus five catches for 30 yards; Jared Goff went 26-of-39 for 206 yards and two scores.
- Josh Allen looked like his 2024 MVP self in Buffalo's 36-31 win over Houston, completing 20 of 29 passes for 334 yards and two touchdowns while rushing six times for 23 yards and two more scores; tight end Dalton Kincaid caught five passes for 130 yards.
- SportsLine's model, on a 53-39 run on top-rated picks since 2024 and up over $7,000 for $100 players since inception, projects 59 combined points and takes the Over 54.5 in 56% of simulations.
- The Over has hit in seven of the Lions' last 10 games and six of the Bills' last 10, per the source.
Why it matters: The Over has cashed in 13 of the last 20 combined games for these teams, and both offenses looked explosive in Week 1 — giving the model real recent data points to back a 56% projection. Bettors also get a spread that moved 2.5 points from open to Bills -5.5, signaling sharp money piling on Buffalo at home.
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