Indiana vs. Northwestern prediction, odds, time: 2026 Week 4 college football Friday picks by proven model — SkimNews

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- Indiana begins defense of its Big Ten championship against Northwestern, entering with a 19-game win streak and a defense allowing 5.3 points per game
- Northwestern averages 460 yards per game but faces a Hoosier defense that has recorded shutouts in all three of its wins
- SportsLine Projection Model simulates the game 10,000 times and projects 48 combined points, favoring the Under (49.5) despite both teams' high yardage totals
- Josh Hoover, Indiana’s TCU transfer quarterback, has thrown 10 touchdowns and zero interceptions through three games
- Turbo Richard leads an Indiana rushing attack averaging 5.7 yards per carry, while Northwestern averages 5.0 yards per carry on the ground
Why it matters: Indiana’s combination of offensive efficiency and elite defense makes them a 20-point favorite, but the model’s lean toward the Under—despite high per-game yardage from both teams—suggests defensive dominance could shape the outcome, affecting betting strategies and perceptions of Indiana’s title sustainability.
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